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Can Gallstones Cause Elevated Liver Enzymes?

By Nation Health MD Jan 25, 2025

Medically reviewed by Medically reviewed by our experts

Medically reviewed by Medically reviewed by our experts

Medically reviewed by 6 min read

Citations 8 citations

can gallstones cause elevated liver enzymes.

Can gallstones cause elevated liver enzymes? This is a common question many people ask when facing digestive health challenges. If you’ve recently received blood test results showing elevated liver enzymes, or you’re dealing with gallstones, you’re not alone. Many adults over 50 face these health concerns, and understanding the connection between gallstones and liver enzymes can help you make informed decisions about your health.

In this guide, we’ll explore the important relationship between gallstones and liver enzymes. We’ll look at how these small, crystal-like deposits in your gallbladder can potentially impact your liver function, what signs to watch for, and what treatment options are available. Whether you’re dealing with gallstones, elevated liver enzymes, or both, we’ll help you understand what these conditions mean for your health and when you should consult your doctor.

Key Article Findings

  • Gallstones can raise liver enzyme levels by blocking bile ducts, but not all gallstones cause problems
  • Watch for warning signs: upper abdominal pain, yellowing skin, and unusual fatigue
  • Early medical attention is crucial – most gallstone problems can be treated successfully with modern procedures

What Are Gallstones?

Think of gallstones as tiny crystals that form in your gallbladder, a small organ that sits just under your liver. These stones develop when substances in your bile (a digestive fluid) become unbalanced. Most gallstones are made of cholesterol, while others form from different substances like calcium and bile pigments.

Your diet, genetics, and even how well your gallbladder empties can influence whether you develop gallstones. About 90% of people with gallstones don’t experience any symptoms at first. However, as these stones grow or move, they can block important passages in your digestive system. This is particularly common in older adults, as the risk of developing gallstones increases with age.

What Causes Elevated Liver Enzymes?

Liver enzymes are special proteins that help your liver carry out its many important jobs, from processing nutrients to filtering toxins from your blood. When these enzymes show up in higher-than-normal amounts in your blood tests, it’s like your liver sending out a distress signal that something isn’t quite right.

Several conditions can trigger this elevation, and the relationship between gallstones and liver enzymes is one important connection to understand. Your liver might show elevated enzyme levels due to:

  • Gallbladder and bile duct problems, including gallstones that block the normal flow of bile
  • Inflammation or infection in the liver
  • Certain medications that affect liver function
  • Regular alcohol consumption
  • Other health conditions like diabetes or heart disease

Not all elevated liver enzymes indicate a serious problem, but they do warrant attention from your healthcare provider to determine the underlying cause.

How Gallstones Affect Liver Enzymes

Can gallstones cause elevated liver enzymes? Yes, and understanding how this happens is crucial for your liver health. Imagine your bile duct system as a network of small pipes that connect your gallbladder and liver to your small intestine. When gallstones move from the gallbladder into these ducts, they can create a blockage – a condition doctors call bile duct obstruction.

When this blockage occurs, bile can’t flow normally through your system. Instead, it backs up into your liver, similar to how a clogged pipe causes water to back up in your sink. This backup forces your liver to work harder, leading to increased enzyme levels in your blood. This connection between bile duct obstruction and liver health can cause several noticeable symptoms:

  • Sudden, intense pain in your upper abdomen, particularly on the right side
  • Yellowing of your skin and the whites of your eyes (jaundice)
  • Dark-colored urine and light-colored stools
  • Fever and chills in some cases
  • Nausea or vomiting
  • Unexplained fatigue

If you experience these symptoms of gallstone-related liver enzyme elevation, especially jaundice or severe abdominal pain, it’s important to seek medical attention promptly. Early treatment can prevent complications and protect your liver health.

Diagnosis and Treatment Options

Your doctor will use several tests to check if gallstones are causing your elevated liver enzymes. They’ll start with blood tests to measure your liver enzyme levels. These tests help show how well your liver is working.

Your doctor will also use imaging tests to get a clear picture of what’s happening inside. An ultrasound can show your gallbladder and bile ducts in real-time. If needed, they might order an MRI for more detailed images. Sometimes, they’ll recommend a special camera procedure called ERCP to look directly into your bile ducts.

  • Watchful Waiting – Not all gallstones require immediate treatment. If they’re not causing symptoms or complications, your doctor may recommend regular monitoring.
  • Medical Management – Your doctor may prescribe medications to manage symptoms and support liver function, particularly if surgery isn’t immediately necessary.
  • ERCP Procedure – This minimally invasive procedure serves both diagnostic and therapeutic purposes. During ERCP, doctors can remove stones blocking the bile ducts and place stents to maintain proper bile flow.
  • Surgical Intervention – For recurring or severe cases, laparoscopic cholecystectomy (gallbladder removal) may be recommended. This modern surgical approach uses small incisions and typically allows for quick recovery.

Remember, prompt diagnosis and appropriate treatment are crucial for preventing long-term liver complications. If you’re experiencing symptoms that might indicate gallstone-related liver problems, seek medical evaluation without delay.

Conclusion

So, can gallstones cause elevated liver enzymes? Yes, they certainly can, especially when they block the bile ducts and interfere with your liver’s normal function. While not all gallstones cause problems, it’s important to pay attention to warning signs like abdominal pain, jaundice, or unusual fatigue.

Remember, your liver and gallbladder work together as a team to keep you healthy. If you notice any concerning symptoms or receive blood test results showing elevated liver enzymes, don’t hesitate to talk to your doctor. With today’s advanced medical treatments, most gallstone-related problems can be managed effectively, especially when caught early.

Take charge of your health by staying informed and seeking medical care when needed. Your liver will thank you for it.

Will liver enzymes go down after gallbladder removal?

Yes, liver enzymes typically return to normal levels after gallbladder removal if gallstones were causing the elevation. However, this process may take several weeks, and it’s important to have follow-up blood tests to confirm normalization.

Can gallbladder issues affect the liver?

Yes, gallbladder problems can directly impact the liver. When gallstones block bile ducts, they can cause bile backup into the liver, leading to elevated enzymes, inflammation, and potential liver damage if left untreated.

How do I know if it’s my liver or gallbladder that hurts?

Gallbladder pain typically occurs in the upper right abdomen and often after meals, while liver pain tends to be duller and more spread out. Gallbladder pain may come and go, but liver discomfort is usually more constant.

1.

Gallstones – Symptoms & causes – Mayo Clinic. (2021). Mayo Clinic.

https://www.mayoclinic.org/diseases-conditions/gallstones/symptoms-causes/syc-20354214
2.

Nakeeb, A., et al. (2002). Gallstones. Annals of Surgery, 235(6), 842–849.

https://pmc.ncbi.nlm.nih.gov/articles/PMC1422514/
3.

Felman, A. (2023). Everything you need to know about gallstones.

https://www.medicalnewstoday.com/articles/153981
5.

Bile duct obstruction. (2024). Cleveland Clinic.

https://my.clevelandclinic.org/health/diseases/bile-duct-obstruction
6.

Barrell, A. (2024). What causes bile duct obstruction?

https://www.medicalnewstoday.com/articles/322095#symptoms
7.

Endoscopic Retrograde Cholangiopancreatography (ERCP). (2024). National Institute of Diabetes and Digestive and Kidney Diseases.

https://www.niddk.nih.gov/health-information/diagnostic-tests/endoscopic-retrograde-cholangiopancreatography
8.

Cholecystectomy (gallbladder removal) – Mayo Clinic. (n.d.).

https://www.mayoclinic.org/tests-procedures/cholecystectomy/about/pac-20384818
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